Measurement of cation transport in vivo in healthy volunteers after the oral administration of lithium carbonate.

نویسندگان

  • A J Wood
  • A Viswalingam
  • P Glue
  • J K Aronson
  • D G Grahame-Smith
چکیده

1. We have measured cation transport in vivo in seven healthy volunteers under control conditions and after they had taken lithium carbonate for 21 days in doses which maintained the serum lithium concentration in the range 0.6-0.8 mmol/l. 2. We have measured cation transport in vivo after the administration of an oral load of rubidium chloride, and have found that, although intra-erythrocytic concentrations of rubidium were significantly lower 1 h after the administration of rubidium when the subjects were taking lithium, there was a significant increase in the rate of uptake of rubidium into the erythrocytes over the subsequent period of the test, suggesting a direct stimulation of sodium, potassium-activated adenosine triphosphatase by lithium. 3. Lithium administration did not affect the plasma concentration versus time profile of rubidium after the rubidium load, implying that the lithium-stimulated uptake of rubidium which occurs in erythrocytes does not necessarily occur in other cell types. 4. These results suggest that previous studies of cation transport using peripheral cells and assay systems in vitro do not necessarily reflect changes in cation transport in vivo in excitable tissues.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Study of Volumetric Changes of Rat's Embryonic Renal Glomeruli, Cortex and Medulla Following Lithium Carbonate Administration by Means of Stereological Method

Purpose: To study the effects of lithium on the fetal rat's kidney and determine volumetric changes by an unbiased stereological method. Materials and Methods: Thirty female and ten male Sprague dawley rats were chosen. Following cohabitation and observation of spermatozoa in the vaginal smear, the pregnant rats were divided into three groups (n=10). Treatment and control groups received 50 mg...

متن کامل

Effect of Honey on CYP3A4 Enzyme and P-Glycoprotein Activity in Healthy Human Volunteers

The activity of cytochrome p450 isozyme 3A4 (CYP3A4) enzyme and P-glycoprotein (P-gp) is modulated by grapefruit juice and herbal drugs. CYP3A4 is the major phase I drug metabolizing enzyme and P-gp is an ATP-dependent drug efflux pump that regulates the intestinal absorption of orally administered drugs. Honey is commonly consumed as a dietary supplement. However, its influence on human CY...

متن کامل

Effect of Lithium on Brain-derived Neurotrophic Factor (BDNF) Level in Patients with Ischemic Stroke: A Clinical Trial

Background and Objectives: Previous studies have indicated that lithium may increase the level of the brain-derived neurotrophic factor (BDNF), which in turn improves the recovery of patients with stroke. In this controlled trial we evaluated the effect of lithium on BDNF serum level in patients with ischemic stroke. Methods: In this randomized controlled...

متن کامل

P89: Effect of Homeopathic Argentum Nitricum on State and Trait Anxiety among Healthy Volunteers in Mashhad

Complementary medicines are being increasingly considered as potential anxiolytics. Homeopathy is one of the old complementary/alternative therapies that is suggested as a cost-effective way to reduce anxiety. Several clinical trials have shown homeopathy superior to placebo however some others have demonstrated that it has similar effects to conventional treatments. Nevertheless the database o...

متن کامل

Bioequivalence Study of Two Formulations of Tramadol Capsules in Healthy Myanmar Volunteers

Background: Tramadol is one of the most commonly used analgesics, thanks to its efficacy and safety. It is widely used in Myanmar for postoperative and cancer pain control. The use of generic drugs has been steadily increasing worldwide, mostly in developing countries. Generic drugs should have efficacy and safety comparable to their innovators or other approved generic products.  Objectives: ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Clinical science

دوره 76 4  شماره 

صفحات  -

تاریخ انتشار 1989